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KMID : 0362720220600090566
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Journal of the Korean Dental Association
2022 Volume.60 No. 9 p.566 ~ p.576
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Characterization of High-Risk Human Papillomavirus according to Periodontitis Severity
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Boonanantanasarn Kanitsak
Baek Jeong-Hwa
Heo Seok-Mo
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Abstract
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The oral microenvironment can be modulated by chronic exposure to microorganisms, their byproduct and host-derived inflammatory response. Recently, high-risk HPV has been reported in periodontitis patients, suggesting that periodontal disease may be a reservoir for high-risk human papillomavirus (HPV). We aimed to examine the relationship between the existence of high-risk HPV 16/18 and the severity of periodontal disease. We collected a total of 342 oral specimens from 20 healthy subjects and 37 periodontitis patients. The specimens included dental plaque, saliva, and tongue scrape samples.
HPV 16 or 18 (high-risk HPV) were detected by real time PCR. The data showed that high-risk HPV in healthy, stage I (mild) periodontitis and stage II (moderate) to stage III/IV (severe) periodontitis were 1.75% (6/342), 2.92% (10/342), and 8.47% (29/342), respectively. Dental plaque and tongue scrape specimens from moderate and severe periodontitis patients showed a significant detection of high-risk HPV in comparison with specimens collected from mild periodontitis and healthy subjects (p<0.01). Collectively, the severity of periodontal disease significantly increased the odds of high-risk HPV-positive samples (p<0.01). Our data suggest that the presence of HPV 16 and 18 in plaque and tongue of periodontitis patient may provide a suitable ecosystem for high-risk HPV.
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KEYWORD
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human papillomavirus (HPV), human papillomavirus 16, human papillomavirus 18, periodontitis
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